Cont@ct:
Mitchel J.Doktycz
Biological & Nanoscale Systems Group
Biosciences Division
Oak Ridge National Laboratories
PO Box 2008 MS 6123
Oak Ridge, TN 37831-6123
Fax: (865) 574-6210
e-mail:

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Phone: (865)-574-6211 (work)
(865)-405-4066 (cell)

 

Background: Scott Retterer is a research scientist in the Biological and Nanoscale Systems Group and shares an appointment in the Center for Nanophase Materials Science (CNMS). Scott received his B.S. in Mechanical Engineering from the University of Illinois at Chicago in 2000 and completed his Ph.D. in Biomedical Engineering at Cornell University, Ithaca, NY in August of 2005. Working in close collaboration with scientists at the Wadsworth Center, New York State Department of Health, his research spanned the fields of microfluidics, neuroscience, fetal screening & genetic analysis, and immunology. Scott was a postdoctoral research fellow in the BNSG laboratory from 2005-2006 before being appointed to a joint staff position in the Biosciences and CNMS divisions.

Scott currently works on a variety of projects that connect state of he art nanofabrication and characterization techniques with fundamental biomedical research.

Research Interests:

1) Influence of nanoscale chemical and biological functionality on cellular and molecular recognition, adhesion, proliferation and differentiation.

2) Impact of surface chemistry and nanostructure on chemical transport and biochemical reaction systems

3) Understanding the influence of local chemical/biochemical environment on the cascade of events associated with the host response to foreign bodies
Publications

1. S.T. Retterer, K.L. Smith, C.S. Bjornnson, J.N. Turner, M.S. Isaacson, and W. Shain, Delivery of compounds to the brain by low-flow, constant pressure infusion from implanted microfluidics, (in preparation)

2. N. Mishra, S. Retterer, T. J. Zieziulewicz, M. Isaacson, D. Szarowski, D.E. Mousseau, D.A. Lawrence, J. N. Turner, On-chip micro-biosensor for the detection of human CD4+ cells based on AC impedance and optical analysis, Biosensors and Bioelectronics. (submitted)

3. S.T. Retterer, K.L. Smith, C.S. Bjornnson, K.B. Neeves. A.J.S. Spence, J.N. Turner, W. Shain, and M.S. Isaacson, Model Silicon Probes with Integrated Fluidic Channels: a potential strategy for controlling the reactive response to implanted devices, IEEE Trans. Biomed. Eng. Nov. 2004; 51(11): 2063-2073.

4. A.P. Russo, S.T. Retterer, A.J. Spence, M.S. Isaacson, R. MacColl, and J.N. Turner, Direct Casting of Polymer Membranes into Microfluidic Devices, Separation Science and Technology. Aug. 2004; 39(11):2515-2530.

5. L. Spataro, J. Dilgen, S. Retterer, A. Spence, M. Isaacson, J. Turner and W. Shain, Dexamethasone Treatment Reduces Astroglia Responses to Inserted Neuroprosthetic Devices in Rat Neocortex, Experimental Neurology, In Press

6. D. Szarowski, M.D. Andersen, S. Retterer, A.J. Spence, M. Isaacson, H.G. Craighead, J. Turner, and W. Shain, Brain Responses to Micro-machined Silicon Devices, Brain Res. 2003 Sep 5; 983(1-2):23-35. PMID 12914963

7. W. Shain, L. Spataro, K. Haberstraw, J. Dilgen, S. Retterer, A. Spence, M. Isaacson and J. Turner, Controlling Cellular reactive Responses Around Neural Prosthetic Devices Using Peripheral and Local Intervention Strategies, IEEE Neural Syst. Rehabil. Eng. 2003 June;11(2) 186-8. PMID 12899270

8. A.P. Russo, D. Apoga, N. Dowell, W. Shain, A. Turner. H.G. Craighead, A.J. Spence, S.T. Retterer, M.S. Isaacson, M.H. Hoch, and J.N. Turner, Microfabricated Plastic Devices from Silicon Using Soft Intermediates. Biomedical Microdevices, 4, 277-283, 2002

9. D Thompson, A. Banerjee, P. Banerjee, T. DeFanti, S. Retterer, Tele-immersive product evaluation: a review and an implementation framework, Robotics and Computer-Integrated Manufacturing 16 (2-3): 181-190 Apr-Jun 2000.

Patents / Patent Applications

1. G. Hagel, S. Retterer, System and Kit for Dispensing Reactive Two Component Materials, Simpson Strong-Tie Company, Inc. SAS033. Patent Pending

Oral Presentations

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, University of Kansas, School of
Engineering, April 14, 2005, Lawrence, KS (invited talk)

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, University of Kansas, Medical Center, April 13, 2005, Kansas City, KS (invited talk)

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, University of Illinois at Urbana-Champaign, April 5, 2005, Urbana, IL (invited talk)

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, Rensselaer Polytechnic Institute, March 10, 2005, Rensselaer, NY (invited talk)

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, Drexel University, January 25, 2005, Philadelphia, PA (invited talk)

S.T. Retterer, Implantable Microfluidics for Local Drug Delivery in the Brain, Oak Ridge National Laboratory, January 13, 2005, Oak Ridge, TN (invited talk)

S.T. Retterer, Model neural prostheses with integrated fluidics for local drug delivery: Addressing the reactive cell and tissue responses to chronic implants, University of California at Santa Cruz, April 20, 2004, Santa Cruz, CA (invited talk)

S.T. Retterer, Model Neural Prostheses with Local Drug Delivery Capabilities, NBTC Platform Series, December 3, 2003, Ithaca, NY, (invited talk)

S.T. Retterer, Quantitative Sensitivity Studies of Dielectrophoretic Separability of Rare Targets in Heterogeneous Populations, BMES 2004 Annual Fall Meeting, Oct. 13-16, Philadelphia, PA. (podium presentation)

S.T. Retterer, Passive Microfluidic Drug Delivery of Biomolecules in Neural Tissue, BMES 2003 Annual Fall Meeting, Oct. 1-4, Nashville, TN. (podium presentation)

Abstracts / Poster presentations

S.T. Retterer, K.L. Smith, C.S. Bjornsson, K.B. Neeves, A.J. Spence, J.N. Turner, W. Shain, M.S. Isaacson, Controlling the Biochemical Environment Surrounding Neural Prostheses Using an Integrated Microfluidic Drug Delivery System, 4th Annual BioMEMs and Nanotech World 2003, Washington, D.C., Aug. 25-26, 2003. (poster presentation)

S.T. Retterer, C.S. Bjornsson, K.L. Smith, J.N. Turner, M.S. Isaacson, W.Shain, Silicon Neural Prostheses with Integrated Fluidics for Intervening in Reactive Responses to Implanted Devices, 34th Annual Neural Prosthesis Workshop. Bethesda, MD, Oct. 21-23, 2003. (poster presentation)

S.T. Retterer, K.L. Smith, C.S. Bjornsson, K.B. Neeves, A.J. Spence, J.N. Turner, M.S. Isaacson, W. Shain, and Microfluidic Drug Delivery: Controlling the Immune Response to Chronically Implanted Neural Prostheses, Society for Neuroscience 33rd Annual Meeting, New Orleans, LA, Nov. 8-12. 2003. (poster presentation)